発表論文(2001~2010)
- Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito H, Taniguchi T, Matsumoto M, Seya T.
Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.
J. Exp. Med. 207, 2675-2687 (2010). - Savitsky D, Yanai H, Tamura T, Taniguchi T and Honda K.
Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus.
Proc. Natl. Acad. Sci. USA 107, 10154-10159 (2010). - Savitsky D, Tamura T, Yanai H, and Taniguchi T.
Regulation of immunity and oncogenesis by the IRF transcription factor family.
Cancer Immunol. Immunother. 59, 489-510 (2010). - Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, Nakasato M, Lu Y, Hangai S, Koshiba R, Savitsky D, Ronfani R, Akira S, Bianchi ME, Honda K, Tamura T, Kodama T, and Taniguchi T.
HMGB proteins function as universal sentinels for nucleic acid-mediated innate immune responses.
Nature 462, 99-103 (2009). - Choi MK, Wang Z, Ban T, Yanai H, Lu Y, Koshiba R, Nakaima Y, Hangai S, Savitsky D, Nakasato M, Negishi H, Takeuchi O, Honda K, Akira S, Tamura T, and Taniguchi T.
A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA.
Proc. Natl. Acad. Sci. USA 106, 17870-17875 (2009). - Nakajima A, Nishimura K, Nakaima Y, Oh T, Noguchi S, Taniguchi T, Tamura T.
Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene.
Proc. Natl. Acad. Sci. USA 106, 12448-12452 (2009). - Taniguchi T.
Aimez-vous Brahms? A story capriccioso from the discovery of a cytokine family and its regulators.
Nat. Immunol. 10, 447-449 (2009). - Suzuki S, Nakasato M, Shibue T, Koshima I, Taniguchi T.
Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells.
Cancer Sci. 100, 759-769 (2009). - Chen HM, Tanaka N, Mitani Y, Oda E, Nozawa H, Chen JZ, Yanai H, Negishi H, Choi MK, Iwasaki T, Yamamoto H, Taniguchi T, Takaoka A.
Critical role for constitutive type I interferon signaling in the prevention of cellular transformation.
Cancer Sci. 100, 449-456 (2009).
- Yanai H, Savitsky D, Tamura T, Taniguchi T.
Regulation of the cytosolic DNA-sensing system in innate immunity: a current view.
Curr. Opin. Immunol. 1, 17-22 (2009).
- Stockinger S, Kastner R, Kernbauer E, Pilz A, Westermayer S, Reutterer B, Soulat D, Stengl G, Vogl C, Frenz T, Waibler Z, Taniguchi T, Rulicke T, Kalinke U, Muller M, Decker T.
Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes.
PLoS Pathog. 5(3), e1000355 (2009).
- Negishi H, Osawa T, Ogami K, Ouyang X, Sakaguchi S, Koshiba R, Yanai H, Seko Y, Shitara H, Bishop K, Yonekawa H, Tamura T, Kaisho T, Taya C, Taniguchi T, Honda K.
A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity.
Proc. Natl. Acad. Sci. USA 105, 20446-20451 (2008).
- Takaoka A, Taniguchi T.
Cytosolic DNA recognition for triggering innate immune responses.
Adv. Drug Deliv. Rev. 60, 847-857 (2008).
- Wang Z, Choi MK, Ban T, Yanai H, Negishi H, Lu Y, Tamura T, Takaoka A, Nishikura K, Taniguchi T.
Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.
Proc. Natl. Acad. Sci. USA 105, 5477-5482 (2008).
- Tamura. T., Yanai. H., Savitsky. D., and Taniguchi. T.
The IRF Family Transcription Factors in Immunity and Oncogenesis.
Annu. Rev. Immunol. 26, 535-584 (2008). - Mizutani T, Tsuji K, Ebihara Y, Taki S, Ohba Y, Taniguchi T, Honda K.
Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling.
Exp. Hematol. 36, 255-264 (2008). - Takaoka A, Tamura T, Taniguchi T.
Interferon regulatory factor family of transcription factors and regulation of oncogenesis.
Cancer Sci. 99, 467-478 (2008). - Couzinet A, Tamura K, Chen HM, Nishimura K, Wang Z, Morishita Y, Takeda K, Yagita H, Yanai H, Taniguchi T, Tamura T.
A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis.
Proc. Natl. Acad. Sci. USA 105, 2556-2561 (2008). - Kano S, Sato K, Morishita Y, Vollstedt S, Kim S, Bishop K, Honda K, Kubo M, Taniguchi T.
The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and T(H)1 versus T(H)-17 differentiation of CD4(+) T cells.
Nat. Immunol. 9, 34-41 (2008). - Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, Lu Y, Miyagishi M, Kodama T, Honda K, Ohba Y, Taniguchi T.
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
Nature 448, 501-505 (2007). - Onoguchi, K., Yoneyama, M., Takemura, A., Akira, S., Taniguchi, T., Namiki, H., and Fujita T.
Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism.
J. Biol. Chem. 282, 7576-7581 (2007). - Yanai, H., Chen, H., Inuzuka, T., Kondo, S., Mak, W. T., Takaoka. A., Honda, K. and Taniguchi, T.
Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression.
Proc. Natl. Acad. Sci. USA 104, 3402-3407 (2007). - Ouyang, X., Negishi, H., Takeda, R., Fujita, Y., Taniguchi, T. and Honda, K.
Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation.
Biochem. Biophys. Res. Commun. 354, 1045-1051 (2007). - Shibue, T., Suzuki, S., Okamoto, H., Yoshida, H., Ohba, Y., Takaoka, A., and Taniguchi, T.
Differential contribution of Puma and Noxa in dual regulation of p53-dependent apoptotic pathways.
EMBO J. 25, 4952-4962 (2006). - Shibue, T. and Taniguchi T.
BH3-only proteins: Integrated control point of apoptosis.
Int. J. Cancer 119, 2036-2043 (2006). - Negishi, H., Fujita, Y., Yanai, H., Sakaguchi, S., Ouyang, X., Shinohara, M., Takayanagi, H., Ohba, Y., Taniguchi, T., and Honda, K.
Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.
Proc. Natl. Acad. Sci. USA 103, 15136-15141 (2006). - Honda, K., Takaoka, A., and Taniguchi, T.
Type I interferon gene induction by the interferon regulatory factor family of transcription factors.
Immunity , 25(3):349-60 (2006). - Honda, K. and Taniguchi, T.
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
Nat. Rev. Immunol. 6, 644-659 (2006). - Honda, K. and Taniguchi, T.
Toll-like Receptor Signaling and IRF Transcription Factors.
IUBMB Life 58, 290-295 (2006). - Yanai H., Mizutani T., Inuzuka T., Honda K., Takaoka A. and Taniguchi T.
IRF family transcription factors in type I interferon induction.
Int. Congress Series 1285, 104-113 (2005). - Shingai M., Inoue N., Okuno T., Okabe M., Akazawa T., Miyamoto Y., Ayata M., Honda K., Kurita-Taniguchi M., Matsumoto M., Ogura H., Taniguchi T., and Seya T.
Wild-Type Measles Virus Infection in Human CD46/CD150-Transgenic Mice: CD11c-Positive Dendritic Cells Establish Systemic Viral Infection.
J. Immunol. 175, 3252-3261 (2005). - Honda K., Yanai H., Takaoka A., and Taniguchi T.
Regulation of the type I IFN induction: a current view.
Int. Immunol. 17, 1367-1378 (2005). - Negishi H., Ohba Y., Yanai H., Takaoka A., Honma K., Yui K., Matsuyama T., Taniguchi T., and Honda K.
Negative regulation of Toll-like-receptor signaling by IRF-4.
Proc. Natl. Acad. Sci. USA 102, 15989-15994 (2005). - Okabe Y., Kawane K., Akira S., Taniguchi T., and Nagata S.
Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation.
J. Exp. Med 202, 1333-1339 (2005). - Takayanagi H., Sato K., Takaoka A., and Taniguchi T.
Interplay between interferon and other cytokine systems in bone metabolism.
Immunol. Rev. , 181-193 (2005). - Honda K., Ohba, Y., Yanai, H., Negishi, H., Mizutani, T., Takaoka, A., Taya, C., and Taniguchi, T.
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type I interferon induction.
Nature 434, 1035-1040 (2005). - Honda K., Yanai H., Negishi H., Asagiri M., Sato M., Mizutani T., Shimada N., Ohba Y., Takaoka A., Yoshida N., and Taniguchi T.
IRF-7 is the master regulator of type-I interferon-dependent immune responses.
Nature 434, 772?777 (2005). - Takaoka A., Yanai H., Kondo S., Duncan G., Negishi H., Mizutani T., Kano S., Honda K., Ohba Y., Mak T.M., and Taniguchi T.
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.
Nature 434, 243-249 (2005). - Taniguchi, T., and Takaoka, A.
Type I interferon system and IRF family of transcription factors in host defense regulation.
Proc. Jpn. Acad. 81, 1-13 (2005). - Takayanagi H, Kim S, Koga T, and Taniguchi T.
Stat1-Mediated Cytoplasmic Attenuation in Osteoimmunology.
J. Cell Biochem. 94, 232-240 (2005). - O'Connel, R. M., Saha, S. K., Vaidya S. A., Bruhn, K. W., Mirandam G. A., Zarnegar, B., Perry, A. K., Nguyen, B., Lane, T. F., Taniguchi, T., Miller, J. F. and Cheng, G.
Type I interferon production enhances susceptibility to Listeria monocytogenes infection.
J. Exp. Med. 200, 437-445 (2004). - Stockinger S, Reutterer B, Schaljo B, Schellack C, Brunner S, Materna T, Yamamoto M, Akira S, Taniguchi T, Murray PJ, Muller M, Decker T.
IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism.
J. Immunol. 173, 7416-7425 (2004). - Honda, K., Yanai, H., Mizutani, T., Negishi, H., Shimada, N., Suzuki, N., Ohba, Y., Takaoka, A., Wen-Chen Yeh, and Taniguchi, T.
Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.
Proc. Natl. Acad. Sci. USA 101, 15416-15421 (2004). - Takaoka, A. and Taniguchi, T.
New aspects of IFN-alpha/beta signalling in immunity, oncogenesis and bone metabolism.
Gann Monogr. Canc. Res. 52, 141-156 (2004). - Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T., Ohnishi, H., Matozaki, T., Kodama, T., Taniguchi, T., Takayanagi, H. and Takai, T.
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis.
Nature 428, 758-763 (2004). - Honda, K., Mizutani, T. and Taniguchi, T.
Negative regulation of IFN-a/b signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells.
Proc. Natl. Acad. Sci. USA 101, 2416-2421 (2004). - Urushibara, M., Takayanagi, H., Koga, T., Kim, S., Isobe, MM., Morishita, Y., Nakagawa, T., Loeffler, M., Kodama, T., Kurosawa, H., and Taniguchi, T.
The antirheumatic drug leflunomide inhibits osteoclastogenesis by interfering with receptor activator of NF-B ligand-stimmulated induction of nuclear factor of activated T cells c1.
Arthritis Rheum. 50, 794-804 (2003). - Honda, K., Sakaguchi, S., Nakajima, C., Watanabe, A., Yanai, H., Matsumoto, M., Ohteki, T., Kaisho, T., Takaoka, A., Akira, S., Seya, T., and Taniguchi, T.
Selective contribution of IFN-a/b signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection.
Proc. Natl. Acad. Sci. USA 100, 10872-10877 (2003). - Shibue, T., Takeda, K., Oda, E., Tanaka, H., Murasawa, H., Takaoka, A., Morishita, Y., Akira, S., Taniguchi, T., and Nobuyuki Tanaka, N.
Integral role of Noxa in p53-mediated apoptotic response.
Genes Dev. 17, 2233-2238 (2003). - Kim, S., Koga T., Isobe, M., Kern, B. E., Yokochi T., Karsenty, G., Taniguchi T., and Takayanagi,H.
Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation.
Genes Dev. 17, 1979-1991 (2003). - Takaoka, A., Hayakawa, K., Yanai, H., Stoiber, D., Negishi, H., Kikuchi, H., Shibue, T., Honda, K., and Taniguchi, T.
Integration of IFN-a/b signalling to p53 responses in tumor suppression and antiviral defense.
Nature 424, 516-523 (2003). - Sakaguchi, S., Negishi, H., Asagiri, M., Nakajima, C., Mizutani, T., Takaoka, A., Honda, K., and Taniguchi, T.
Essential role of IRF-3 in lipopolysaccharide-induced interferon-β gene expression and endotoxin shock.
Biochem. Biophys. Res. Commun. 306, 806-866 (2003). - Takaoka, A., and Taniguchi, T.
New aspects of IFN-α/βsignaling in immunity, oncogenesis and bone metabolism.
Cancer Sci. 94, 405-411 (2003). - Takayanagi, H., Kim, S., Koga, T., and Taniguchi, T.
Induction and activation of the transcription factor NFATc1(NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.
Dev. Cell 3, 889-901 (2002). - Takayanagi, H., Kim, S., and Taniguchi, T.
Signaling crosstalk between RANKLand interferons in osteoclast differentiation.
Arthritis Res. , 4 (suppl 3):S227-S232 (2002). - Takayanagi, H., Kim, S., Matsuo, K., Suzuki, H., Suzuki, T., Sato, K., Yokochi, T., Oda, H., Nakamura, K., Ida, N., Wagner, E. F., and Taniguchi, T.
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β.
Nature 416, 744-749 (2002). - Ogasawara, K., Hida, S., Weng, Y., Saiura, A., Sato, K.,Takayanagi, H., Sakaguchi, S., Yokochi, T., Kodama, T., Naitoh, M., De Martino, J., and Taniguchi, T.
Requirement of the IFN-α/β-induced CXCR3 chemokine signaling for CD8+ T cell activation.
Genes to Cells 7, 309-320 (2002). - Taniguchi, T., Takaoka, A.
Interferon-α/β system in antiviral response: Multimodal machinery of gene regulation by the IRF family of transcription factors.
Curr. Opin. Immunol. 14, 111-116 (2002). - Sato, K., Hida, S., Takayanagi, H., Yokochi, T., Kayagaki, N.,Takeda, K., Yagita, H. Okumura, K., Tanaka, N., Taniguchi, T., and Ogasawara, K.
Antiviral response by natural killer cells through TRAIL gene induction by IFN-α/β.
Eur. J. Immunol. 31, 3138-3146 (2001). - Mitani, Y., Takaoka, A., Kim, S. H., Kato, Y., Yokochi, T., Tanaka, N., and Taniguchi, T.
Cross talk of the interferon-α/β signaling complex with gp130 for effective interleukin-6 signaling.
Genes to Cells 6, 631-640 (2001). - Hata, N. Sato, M. Takaoka, A. Asagiri, M. Tanaka, N. Taniguchi, T.
Constitutive IFN-α/β signal for efficient IFN-α/β gene induction by virus.
Biochem. Biophys. Res. Commun. 285, 518-525 (2001). - Nakaya, T., Sato, M., Hata, N., Asagiri, M., Suemori, H., Noguchi, S., Tanaka, N., Taniguchi, T.
Gene induction pathways mediated by distinct IRFs during viral infection.
Biochem. Biophys. Res. Commun. 283, 1150-1156 (2001). - Taniguchi, T. and Takaoka, A.
A weak signal for strong responses: Interferon-α/β Revisited.
Nat. Rev. Mol. Cell Biol. 2, 378-386 (2001). - Taniguchi, T., Ogasawara, K., Takaoka, A, and Tanaka, N.
IRF family of transcription factors as regulators of host defense.
Ann. Rev. Immunol. 19, 623-655 (2001).
